Tissue expression of UTRN - Summary - The Human Protein Atlas

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UTRN

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	UTRN
Gene description	Utrophin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA018894 , CAB016348
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UTRN (HGNC Symbol)
Synonyms	DMDL, DRP, DRP1
Description	Utrophin (HGNC Symbol)
Entrez gene summary	This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q24.2
Chromosome location (bp)	144285701 - 144853034
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152818 (version 83.38)
Entrez gene	7402
UniProt	P46939 (UniProt - Evidence at protein level)
neXtProt	NX_P46939
Antibodypedia	UTRN antibodies

PROTEIN BROWSER

UTRN-001	UTRN-002	UTRN-003	UTRN-004	UTRN-005	UTRN-006	UTRN-007	UTRN-008	UTRN-010	UTRN-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UTRN-001 ENSP00000356515 ENST00000367545	P46939 [Direct mapping] Utrophin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002162 [dystroglycan binding] GO:0003779 [actin binding] GO:0005178 [integrin binding] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0007517 [muscle organ development] GO:0007528 [neuromuscular junction development] GO:0008270 [zinc ion binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016203 [muscle attachment] GO:0017166 [vinculin binding] GO:0019901 [protein kinase binding] GO:0030054 [cell junction] GO:0030175 [filopodium] GO:0030426 [growth cone] GO:0030864 [cortical actin cytoskeleton] GO:0031527 [filopodium membrane] GO:0031594 [neuromuscular junction] GO:0042383 [sarcolemma] GO:0043234 [protein complex] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] GO:0070938 [contractile ring] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	3433 aa 394.5 kDa	No	0
UTRN-002 ENSP00000396276 ENST00000421035	A0A0A0MSM3 [Direct mapping] Utrophin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] Show all	154 aa 17.4 kDa	No	0
UTRN-003 ENSP00000390879 ENST00000433557	Q5SYY2 [Direct mapping] Utrophin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	47 aa 5.5 kDa	No	0
UTRN-004 ENSP00000398923 ENST00000432686	Q5JT45 [Direct mapping] Utrophin Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	181 aa 20.8 kDa	No	0
UTRN-005 ENSP00000404205 ENST00000417142	Q5JT44 [Direct mapping] Utrophin Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	184 aa 21 kDa	No	0
UTRN-006 ENSP00000387927 ENST00000455022	Q5JT49 [Direct mapping] Utrophin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	186 aa 21.4 kDa	No	0
UTRN-007 ENSP00000356494 ENST00000367524	H0Y337 [Direct mapping] Utrophin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	251 aa 28.5 kDa	No	0
UTRN-008 ENSP00000356495 ENST00000367525	Q5T098 [Direct mapping] Utrophin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.8 kDa	No	0
UTRN-010 ENSP00000356496 ENST00000367526	Q5T097 [Direct mapping] Utrophin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	988 aa 113.4 kDa	No	0
UTRN-013 ENSP00000487153 ENST00000628146	A0A0D9SG57 [Direct mapping] Utrophin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] Show all	150 aa 17 kDa	No	0

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The Human Protein Atlas

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