Expression of GRM1 in cancer - Summary - The Human Protein Atlas

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GRM1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRM1
Gene description	Glutamate receptor, metabotropic 1
Protein class	Disease related genes G-protein coupled receptors Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA015701
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015701

GENE INFORMATION
Gene name	GRM1 (HGNC Symbol)
Synonyms	GPRC1A, mGlu1, MGLUR1, PPP1R85
Description	Glutamate receptor, metabotropic 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Chromosome	6
Cytoband	q24.3
Chromosome location (bp)	146027646 - 146437598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152822 (version 83.38)
Entrez gene	2911
UniProt	Q13255 (UniProt - Evidence at protein level)
neXtProt	NX_Q13255
Antibodypedia	GRM1 antibodies

PROTEIN BROWSER

GRM1-001	GRM1-002	GRM1-019	GRM1-020	GRM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM1-001 ENSP00000282753 ENST00000282753	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	1194 aa 132.4 kDa	Yes	7
GRM1-002 ENSP00000424095 ENST00000492807	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	906 aa 101.3 kDa	Yes	7
GRM1-019 ENSP00000347437 ENST00000355289	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	908 aa 101.5 kDa	Yes	7
GRM1-020 ENSP00000425599 ENST00000507907	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	906 aa 101.3 kDa	Yes	7
GRM1-201 ENSP00000354896 ENST00000361719	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030425 [dendrite] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0043005 [neuron projection] GO:0043408 [regulation of MAPK cascade] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051930 [regulation of sensory perception of pain] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0071257 [cellular response to electrical stimulus] Show all	1194 aa 132.4 kDa	Yes	7

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