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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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RAB3C
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

RAB3C

Gene description

RAB3C, member RAS oncogene family

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS, adrenal medulla and islets of Langerhans.

ANTIBODY IHC RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA003160
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003160

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Carcinoids showed distinct cytoplasmic staining. Neuropil was positive in some high grade gliomas. In a few pancreatic- and colorectal cancers, mucus was distinctly stained.

GENE INFORMATION

Gene name

RAB3C

Synonyms

Description

RAB3C, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

RAB proteins, such as RAB3C, are small GTPases implicated in the regulation of vesicular trafficking between membrane compartments (Cheng et al., 2002 [PubMed 12296628]).[supplied by OMIM, Jun 2009]

Chromosome

5

Cytoband

q11.2

Chromosome location (bp)

58582221 - 58859394

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152932 (version 83.38)

Entrez gene

115827

UniProt

Q96E17 (UniProt - Evidence at transcript level)

neXtProt

NX_Q96E17

Antibodypedia

RAB3C antibodies

PROTEIN BROWSER

RAB3C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAB3C-001
ENSP00000282878
ENST00000282878
Q96E17 [Direct mapping]
Ras-related protein Rab-3C
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008021 [synaptic vesicle]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019882 [antigen processing and presentation]
GO:0030667 [secretory granule membrane]
GO:0031489 [myosin V binding]
GO:0031982 [vesicle]
GO:0032482 [Rab protein signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
Show all
227 aa
26 kDa
No 0

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