Cell atlas - MARVELD2 - The Human Protein Atlas

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MARVELD2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	MARVELD2
Gene description	MARVEL domain containing 2
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions.
RNA cell category	Cell line enhanced (SCLC-21H, BEWO, CAPAN-2, T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061726
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, BEWO, CAPAN-2, T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions.

Main location

Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061726	MCF7	Cell Junctions
	HPA061726	U-2 OS	No staining

GENE INFORMATION
Gene name	MARVELD2 (HGNC Symbol)
Synonyms	DFNB49, FLJ30532, MRVLDC2, TRIC
Description	MARVEL domain containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	5
Cytoband	q13.2
Chromosome location (bp)	69415112 - 69444330
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152939 (version 83.38)
Entrez gene	153562
UniProt	Q8N4S9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4S9
Antibodypedia	MARVELD2 antibodies

PROTEIN BROWSER

MARVELD2-002	MARVELD2-003	MARVELD2-004	MARVELD2-006	MARVELD2-007	MARVELD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARVELD2-002 ENSP00000396244 ENST00000454295	Q8N4S9 [Direct mapping] MARVEL domain-containing protein 2 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0007605 [sensory perception of sound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0045216 [cell-cell junction organization] GO:0061028 [establishment of endothelial barrier] GO:0061689 [tricellular tight junction] GO:0070830 [bicellular tight junction assembly] Show all	546 aa 62.8 kDa	No	4
MARVELD2-003 ENSP00000414776 ENST00000436532	A1BQX2 [Direct mapping] MARVEL domain-containing protein 2; Tricellulin isoform c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007605 [sensory perception of sound] GO:0016021 [integral component of membrane] GO:0045216 [cell-cell junction organization] GO:0061689 [tricellular tight junction] Show all	442 aa 51.1 kDa	No	2
MARVELD2-004 ENSP00000423490 ENST00000512803	D6RA09 [Direct mapping] MARVEL domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007605 [sensory perception of sound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0045216 [cell-cell junction organization] GO:0061689 [tricellular tight junction] Show all	516 aa 59 kDa	No	4
MARVELD2-006 ENSP00000323264 ENST00000325631	Q8N4S9 [Direct mapping] MARVEL domain-containing protein 2 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0007605 [sensory perception of sound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0033010 [paranodal junction] GO:0043220 [Schmidt-Lanterman incisure] GO:0045216 [cell-cell junction organization] GO:0061028 [establishment of endothelial barrier] GO:0061689 [tricellular tight junction] GO:0070830 [bicellular tight junction assembly] Show all	558 aa 64.2 kDa	No	4
MARVELD2-007 ENSP00000421902 ENST00000515844	D6RAH8 [Direct mapping] MARVEL domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007605 [sensory perception of sound] GO:0045216 [cell-cell junction organization] GO:0061689 [tricellular tight junction] Show all	145 aa 16.3 kDa	No	0
MARVELD2-201 ENSP00000398922 ENST00000413223	A1BQX2 [Direct mapping] MARVEL domain-containing protein 2; Tricellulin isoform c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007605 [sensory perception of sound] GO:0016021 [integral component of membrane] GO:0045216 [cell-cell junction organization] GO:0061689 [tricellular tight junction] Show all	442 aa 51.1 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.