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Several gliomas showed nuclear staining. Moderate cytoplasmic positivity was displayed in renal cancer and in a few testis, urothelial and liver tumors. Most other malignancies were negative.
GENE INFORMATION
Gene name
ZIC1 (HGNC Symbol)
Synonyms
ZIC, ZNF201
Description
Zic family member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]