Expression of CWC27 in cancer - Summary - The Human Protein Atlas

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CWC27

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CWC27
Gene description	CWC27 spliceosome-associated protein homolog
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA020344 , HPA024149
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020344	HPA024149

GENE INFORMATION
Gene name	CWC27 (HGNC Symbol)
Synonyms	NY-CO-10, SDCCAG-10, SDCCAG10
Description	CWC27 spliceosome-associated protein homolog (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	64768930 - 65018763
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153015 (version 83.38)
Entrez gene	10283
UniProt	Q6UX04 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UX04
Antibodypedia	CWC27 antibodies

PROTEIN BROWSER

CWC27-001	CWC27-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CWC27-001 ENSP00000370460 ENST00000381070	Q6UX04 [Direct mapping] Peptidyl-prolyl cis-trans isomerase CWC27 homolog Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0071013 [catalytic step 2 spliceosome] Show all	472 aa 53.8 kDa	No	0
CWC27-005 ENSP00000426802 ENST00000508024	D6REK3 [Direct mapping] Peptidyl-prolyl cis-trans isomerase CWC27 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	381 aa 43 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.