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CENPH

GENERAL INFORMATION

Gene name

 CENPH

Gene description

 Centromere protein H

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and/or cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036494
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), ovarian cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Ovarian cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA036494

GENE INFORMATION

Gene name

 CENPH

Synonyms

Description

 Centromere protein H (HGNC Symbol)

Entrez gene summary

 Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 69189548 - 69210357

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153044 (version 83.38)

Entrez gene

 64946

UniProt

 Q9H3R5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3R5

Antibodypedia

 CENPH antibodies

PROTEIN BROWSER
CENPH-001
CENPH-002
CENPH-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPH-001
ENSP00000283006
ENST00000283006
Q9H3R5 [Direct mapping]
Centromere protein H
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0043515 [kinetochore binding]
GO:0051382 [kinetochore assembly]
GO:0051383 [kinetochore organization]
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 247 aa
28.5 kDa 		No 0
CENPH-002
ENSP00000426014
ENST00000515001
B3KVZ3 [Direct mapping]
Centromere protein H; Centromere protein H, isoform CRA_b; cDNA FLJ41767 fis, clone IMR322006495, highly similar to Centromere protein H (Kinetochore protein CENP-H)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000776 [kinetochore]
GO:0051382 [kinetochore assembly]
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 228 aa
26.2 kDa 		No 0
CENPH-003
ENSP00000423936
ENST00000502689
H0Y9E6 [Direct mapping]
Centromere protein H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000776 [kinetochore]
GO:0051382 [kinetochore assembly]
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 187 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.