Expression of TXNDC11 in cancer - Summary - The Human Protein Atlas

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TXNDC11

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TXNDC11
Gene description	Thioredoxin domain containing 11
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA041174 , HPA041390
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and glioma (unfavourable).
Endometrial cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041174	HPA041390

GENE INFORMATION
Gene name	TXNDC11 (HGNC Symbol)
Synonyms	EFP1
Description	Thioredoxin domain containing 11 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.13
Chromosome location (bp)	11679080 - 11742878
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153066 (version 83.38)
Entrez gene	51061
UniProt	Q6PKC3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PKC3
Antibodypedia	TXNDC11 antibodies

PROTEIN BROWSER

TXNDC11-001	TXNDC11-002	TXNDC11-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNDC11-001 ENSP00000283033 ENST00000283033	Q6PKC3 [Direct mapping] Thioredoxin domain-containing protein 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016021 [integral component of membrane] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] Show all	958 aa 107.5 kDa	No	1
TXNDC11-002 ENSP00000349439 ENST00000356957	Q6PKC3 [Direct mapping] Thioredoxin domain-containing protein 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016021 [integral component of membrane] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] Show all	985 aa 110.5 kDa	No	1
TXNDC11-009 ENSP00000458263 ENST00000575591	I3L0Q4 [Direct mapping] Thioredoxin domain-containing protein 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0006457 [protein folding] GO:0034976 [response to endoplasmic reticulum stress] Show all	205 aa 23.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.