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ACMSD

GENERAL INFORMATION

Gene name

 ACMSD

Gene description

 Aminocarboxymuconate semialdehyde decarboxylase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, renal cancer)
HPA (cell line):Cell line enriched (RPTEC TERT1)
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in renal tubules and hepatocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA010533 , HPA011179
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010533
HPA011179

GENE INFORMATION

Gene name

 ACMSD

Synonyms

Description

 Aminocarboxymuconate semialdehyde decarboxylase (HGNC Symbol)

Entrez gene summary

 The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

Chromosome

 2

Cytoband

 q21.3

Chromosome location (bp)

 134838547 - 134902034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153086 (version 83.38)

Entrez gene

 130013

UniProt

 Q8TDX5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDX5

Antibodypedia

 ACMSD antibodies

PROTEIN BROWSER
ACMSD-001
ACMSD-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACMSD-001
ENSP00000348459
ENST00000356140
Q8TDX5 [Direct mapping]
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
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Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0001760 [aminocarboxymuconate-semialdehyde decarboxylase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0016787 [hydrolase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046874 [quinolinate metabolic process]
GO:0070062 [extracellular exosome]
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 336 aa
38 kDa 		No 0
ACMSD-002
ENSP00000376659
ENST00000392928
Q8TDX5 [Direct mapping]
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001760 [aminocarboxymuconate-semialdehyde decarboxylase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0016787 [hydrolase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046874 [quinolinate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 278 aa
31.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.