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ACOXL

GENERAL INFORMATION

Gene name

 ACOXL

Gene description

 Acyl-CoA oxidase-like

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (lung cancer, prostate cancer, testis cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (A-431, RPMI-8226, RT4, U-266/70)
HPA (normal tissue):Group enriched (epididymis, lung, parathyroid gland, prostate, testis, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending retesting. Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA035392 , HPA035393
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (lung cancer, prostate cancer, testis cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035392
HPA035393

GENE INFORMATION

Gene name

 ACOXL (HGNC Symbol)

Synonyms

 FLJ11042

Description

 Acyl-CoA oxidase-like (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q13

Chromosome location (bp)

 110732573 - 111118222

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153093 (version 83.38)

Entrez gene

 55289

UniProt

 Q9NUZ1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NUZ1

Antibodypedia

 ACOXL antibodies

PROTEIN BROWSER
ACOXL-001
ACOXL-002
ACOXL-004
ACOXL-005
ACOXL-007
ACOXL-011
ACOXL-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOXL-001
ENSP00000374461
ENST00000389811
Q9NUZ1 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005575 [cellular_component]
GO:0005777 [peroxisome]
GO:0006635 [fatty acid beta-oxidation]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
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 547 aa
61.8 kDa 		No 0
ACOXL-002
ENSP00000343717
ENST00000340561
Q9NUZ1 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005575 [cellular_component]
GO:0005777 [peroxisome]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 279 aa
30.7 kDa 		No 0
ACOXL-004
ENSP00000394701
ENST00000448863
C9JQI3 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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 70 aa
7.7 kDa 		No 0
ACOXL-005
ENSP00000406774
ENST00000433706
H7C2M3 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
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GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
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 161 aa
17.9 kDa 		No 0
ACOXL-007
ENSP00000393823
ENST00000441974
H7C0A6 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
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Predicted intracellular proteins
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GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
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 93 aa
10.6 kDa 		No 0
ACOXL-011
ENSP00000387832
ENST00000417074
A0A0C4DG10 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003997 [acyl-CoA oxidase activity]
GO:0005777 [peroxisome]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 355 aa
40.5 kDa 		No 0
ACOXL-013
ENSP00000407761
ENST00000439055
Q9NUZ1 [Direct mapping]
Acyl-coenzyme A oxidase-like protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005575 [cellular_component]
GO:0005777 [peroxisome]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 580 aa
65.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.