Expression of CETN3 in cancer - Summary

GENERAL INFORMATION
Gene name	CETN3
Gene description	Centrin, EF-hand protein, 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues combined with membranous and nuclear expression in several different cell types, highly abundant in testis, striated and smooth muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035608
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035608

GENE INFORMATION
Gene name	CETN3 (HGNC Symbol)
Synonyms	CEN3
Description	Centrin, EF-hand protein, 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	5
Cytoband	q14.3
Chromosome location (bp)	90392261 - 90409786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153140 (version 83.38)
Entrez gene	1070
UniProt	O15182 (UniProt - Evidence at protein level)
neXtProt	NX_O15182
Antibodypedia	CETN3 antibodies

PROTEIN BROWSER

CETN3-001	CETN3-002	CETN3-003	CETN3-004	CETN3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CETN3-001 ENSP00000283122 ENST00000283122	O15182 [Direct mapping] Centrin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0007067 [mitotic nuclear division] GO:0007098 [centrosome cycle] GO:0051301 [cell division] Show all	167 aa 19.5 kDa	No	0
CETN3-002 ENSP00000428259 ENST00000522083	E5RJF8 [Direct mapping] Centrin-3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0008017 [microtubule binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032391 [photoreceptor connecting cilium] GO:0035869 [ciliary transition zone] GO:0036064 [ciliary basal body] Show all	191 aa 22.4 kDa	No	0
CETN3-003 ENSP00000430361 ENST00000522864	E5RFM2 [Direct mapping] Centrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005813 [centrosome] Show all	153 aa 18 kDa	No	0
CETN3-004 ENSP00000430409 ENST00000522565	E5RK82 [Direct mapping] Centrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005813 [centrosome] Show all	156 aa 18.3 kDa	No	0
CETN3-005 ENSP00000429875 ENST00000522842	E5RH67 [Direct mapping] Centrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005813 [centrosome] Show all	111 aa 12.9 kDa	No	0