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Renal, hepatocellular and thyroid carcinomas as well as several endometrial cancers showed strong cytoplasmic immunoreactivity with a granular pattern while fractions of prostate, colorectal, pancreatic and cervical cancers displayed moderate to strong positivity. Remaining cancer were generally negative.
GENE INFORMATION
Gene name
MERTK (HGNC Symbol)
Synonyms
c-Eyk, mer, RP38, Tyro12
Description
MER proto-oncogene, tyrosine kinase (HGNC Symbol)
Entrez gene summary
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]