Expression of TMEM87B in cancer - Summary - The Human Protein Atlas

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TMEM87B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM87B
Gene description	Transmembrane protein 87B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Highly expressed in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035183
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable), head and neck cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035183

GENE INFORMATION
Gene name	TMEM87B (HGNC Symbol)
Synonyms	FLJ14681
Description	Transmembrane protein 87B (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q13
Chromosome location (bp)	112055223 - 112119318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153214 (version 83.38)
Entrez gene	84910
UniProt	Q96K49 (UniProt - Evidence at protein level)
neXtProt	NX_Q96K49
Antibodypedia	TMEM87B antibodies

PROTEIN BROWSER

TMEM87B-001	TMEM87B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM87B-001 ENSP00000283206 ENST00000283206	Q96K49 [Direct mapping] Transmembrane protein 87B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	555 aa 63.5 kDa	Yes	7
TMEM87B-002 ENSP00000393998 ENST00000452614	H7C0B3 [Direct mapping] Transmembrane protein 87B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	184 aa 21.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.