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Cacner tissues displayed weak to moderate cytoplasmic positivity. Nucleolar staining was observed in a few cases of melanoma and breast cancer. Occasional cases of thyroid, prostate, ovarian and skin cancers were strongly stained. Many cases of lymphomas, renal, liver and cervical cancers were negative.
GENE INFORMATION
Gene name
SCN3A (HGNC Symbol)
Synonyms
Nav1.3
Description
Sodium channel, voltage gated, type III alpha subunit (HGNC Symbol)
Entrez gene summary
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]