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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADGRF1
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADGRF1

Gene description

Adhesion G protein-coupled receptor F1

Protein class

G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (A-431, CAPAN-2, HaCaT, PC-3, RPTEC TERT1, RT4)
HPA (normal tissue):Tissue enhanced (esophagus, kidney, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in subset of urothelial cells, seminiferous ducts in testis and most glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

External characterization data supports antibody staining. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA038438
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY

HPA038438

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most colorectal and a few cases of prostate, ovarian, thyroid and testis cancer showed moderate membranous staining. Remaining cancers were mainly negative.

GENE INFORMATION

Gene name

ADGRF1 (HGNC Symbol)

Synonyms

GPR110, hGPCR36, PGR19

Description

Adhesion G protein-coupled receptor F1 (HGNC Symbol)

Entrez gene summary

Chromosome

6

Cytoband

p12.3

Chromosome location (bp)

46997703 - 47042363

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153292 (version 83.38)

Entrez gene

266977

UniProt

Q5T601 (UniProt - Evidence at protein level)

neXtProt

NX_Q5T601

Antibodypedia

ADGRF1 antibodies

PROTEIN BROWSER

ADGRF1-001
ADGRF1-003
ADGRF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADGRF1-001
ENSP00000360299
ENST00000371253
Q5T601 [Direct mapping]
Adhesion G-protein coupled receptor F1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
910 aa
101.4 kDa
Yes 7
ADGRF1-003
ENSP00000360289
ENST00000371243
Q5T601 [Direct mapping]
Adhesion G-protein coupled receptor F1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
218 aa
24.9 kDa
Yes 0
ADGRF1-201
ENSP00000283297
ENST00000283297
A0A0C4DH10 [Direct mapping]
Adhesion G-protein-coupled receptor F1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
713 aa
78.8 kDa
No 7

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