Expression of ADGRF1 in cancer - Summary

GENERAL INFORMATION
Gene name	ADGRF1
Gene description	Adhesion G protein-coupled receptor F1
Protein class	G-protein coupled receptors Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (A-431, CAPAN-2, HaCaT, PC-3, RPTEC TERT1, RT4)
HPA (normal tissue):	Tissue enhanced (esophagus, kidney, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in subset of urothelial cells, seminiferous ducts in testis and most glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038438
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038438

GENE INFORMATION
Gene name	ADGRF1 (HGNC Symbol)
Synonyms	GPR110, hGPCR36, PGR19
Description	Adhesion G protein-coupled receptor F1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	46997703 - 47042363
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153292 (version 83.38)
Entrez gene	266977
UniProt	Q5T601 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T601
Antibodypedia	ADGRF1 antibodies

PROTEIN BROWSER

ADGRF1-001	ADGRF1-003	ADGRF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRF1-001 ENSP00000360299 ENST00000371253	Q5T601 [Direct mapping] Adhesion G-protein coupled receptor F1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	910 aa 101.4 kDa	Yes	7
ADGRF1-003 ENSP00000360289 ENST00000371243	Q5T601 [Direct mapping] Adhesion G-protein coupled receptor F1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	218 aa 24.9 kDa	Yes	0
ADGRF1-201 ENSP00000283297 ENST00000283297	A0A0C4DH10 [Direct mapping] Adhesion G-protein-coupled receptor F1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	713 aa 78.8 kDa	No	7