Cell atlas - CMTM7 - The Human Protein Atlas

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CMTM7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CMTM7
Gene description	CKLF-like MARVEL transmembrane domain containing 7
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA077409
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077409	Hep G2	Plasma membrane	Intensity
	HPA077409	PC-3	No staining
	HPA077409	U-2 OS	No staining

GENE INFORMATION
Gene name	CMTM7 (HGNC Symbol)
Synonyms	CKLFSF7, FLJ30992
Description	CKLF-like MARVEL transmembrane domain containing 7 (HGNC Symbol)
Entrez gene summary	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. The protein encoded by this gene is highly expressed in leukocytes, but its exact function is unknown. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.3
Chromosome location (bp)	32391671 - 32483067
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153551 (version 83.38)
Entrez gene	112616
UniProt	Q96FZ5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96FZ5
Antibodypedia	CMTM7 antibodies

PROTEIN BROWSER

CMTM7-001	CMTM7-002	CMTM7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CMTM7-001 ENSP00000335605 ENST00000334983	Q96FZ5 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 7 A0A024R2L3 [Target identity:100%; Query identity:100%] CKLF-like MARVEL transmembrane domain containing 7, isoform CRA_b Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002337 [B-1a B cell differentiation] GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	175 aa 18.8 kDa	No	3
CMTM7-002 ENSP00000283621 ENST00000349718	Q96FZ5 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 7 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	142 aa 15.5 kDa	No	3
CMTM7-005 ENSP00000440333 ENST00000465248	H0YFU6 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	163 aa 18.1 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.