Expression of TMPRSS11D in cancer - Summary

GENERAL INFORMATION
Gene name	TMPRSS11D
Gene description	Transmembrane protease, serine 11D
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues, additional membranous expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA052834
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA052834

GENE INFORMATION
Gene name	TMPRSS11D
Synonyms
Description	Transmembrane protease, serine 11D (HGNC Symbol)
Entrez gene summary	This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q13.2
Chromosome location (bp)	67820876 - 67884032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153802 (version 83.38)
Entrez gene	9407
UniProt	O60235 (UniProt - Evidence at protein level)
neXtProt	NX_O60235
Antibodypedia	TMPRSS11D antibodies

PROTEIN BROWSER

TMPRSS11D-001	TMPRSS11D-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMPRSS11D-001 ENSP00000283916 ENST00000283916	O60235 [Direct mapping] Transmembrane protease serine 11D Transmembrane protease serine 11D non-catalytic chain Transmembrane protease serine 11D catalytic chain Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007585 [respiratory gaseous exchange] GO:0008233 [peptidase activity] GO:0070062 [extracellular exosome] Show all	418 aa 46.3 kDa	No	1
TMPRSS11D-007 ENSP00000421381 ENST00000514868	H0Y8K7 [Direct mapping] Transmembrane protease serine 11D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.1 kDa	No	0