Cell atlas - TRIP12 - The Human Protein Atlas

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TRIP12

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TRIP12
Gene description	Thyroid hormone receptor interactor 12
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036835
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036835	RH-30	Nuclear speckles
	HPA036835	RT4	Nuclear speckles
	HPA036835	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	TRIP12 (HGNC Symbol)
Synonyms	KIAA0045
Description	Thyroid hormone receptor interactor 12 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q36.3
Chromosome location (bp)	229763838 - 229923239
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153827 (version 83.38)
Entrez gene	9320
UniProt	Q14669 (UniProt - Evidence at protein level)
neXtProt	NX_Q14669
Antibodypedia	TRIP12 antibodies

PROTEIN BROWSER

TRIP12-001	TRIP12-003	TRIP12-004	TRIP12-005	TRIP12-006	TRIP12-007	TRIP12-008	TRIP12-009	TRIP12-014	TRIP12-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIP12-001 ENSP00000283943 ENST00000283943	Q14669 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0009790 [embryo development] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046966 [thyroid hormone receptor binding] GO:0061630 [ubiquitin protein ligase activity] GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination] GO:2000780 [negative regulation of double-strand break repair] Show all	1992 aa 220.4 kDa	No	0
TRIP12-003 ENSP00000386388 ENST00000409677	G5E9G6 [Direct mapping] E3 ubiquitin-protein ligase TRIP12; Thyroid hormone receptor interactor 12, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		430 aa 45.3 kDa	No	0
TRIP12-004 ENSP00000373696 ENST00000389044	Q14669 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0009790 [embryo development] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046966 [thyroid hormone receptor binding] GO:0061630 [ubiquitin protein ligase activity] GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination] GO:2000780 [negative regulation of double-strand break repair] Show all	2040 aa 225.5 kDa	No	0
TRIP12-005 ENSP00000373697 ENST00000389045	Q14669 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0008270 [zinc ion binding] GO:0009790 [embryo development] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046966 [thyroid hormone receptor binding] GO:0061630 [ubiquitin protein ligase activity] GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination] GO:2000780 [negative regulation of double-strand break repair] Show all	1722 aa 192.1 kDa	No	0
TRIP12-006 ENSP00000409460 ENST00000435716	C9JSX9 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 16.7 kDa	No	0
TRIP12-007 ENSP00000389827 ENST00000430954	C9JLD7 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 20.5 kDa	No	0
TRIP12-008 ENSP00000414385 ENST00000428959	C9JLJ5 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.1 kDa	No	0
TRIP12-009 ENSP00000400967 ENST00000453485	H7C1L9 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		217 aa 22.4 kDa	No	0
TRIP12-014 ENSP00000342442 ENST00000343290	F8W9P3 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.6 kDa	No	0
TRIP12-016 ENSP00000408330 ENST00000418123	H7C2Y1 [Direct mapping] E3 ubiquitin-protein ligase TRIP12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	187 aa 21.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.