Expression of SLC5A10 in cancer - Summary - The Human Protein Atlas

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SLC5A10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC5A10
Gene description	Solute carrier family 5 (sodium/sugar cotransporter), member 10
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Cell line enhanced (U-937)
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA052014
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052014

GENE INFORMATION
Gene name	SLC5A10 (HGNC Symbol)
Synonyms	SGLT5
Description	Solute carrier family 5 (sodium/sugar cotransporter), member 10 (HGNC Symbol)
Entrez gene summary	This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	18950345 - 19022595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154025 (version 83.38)
Entrez gene	125206
UniProt	A0PJK1 (UniProt - Evidence at protein level)
neXtProt	NX_A0PJK1
Antibodypedia	SLC5A10 antibodies

PROTEIN BROWSER

SLC5A10-001	SLC5A10-002	SLC5A10-003	SLC5A10-004	SLC5A10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A10-001 ENSP00000379008 ENST00000395647	A0PJK1 [Direct mapping] Sodium/glucose cotransporter 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	612 aa 66.2 kDa	No	>9
SLC5A10-002 ENSP00000379007 ENST00000395645	A0PJK1 [Direct mapping] Sodium/glucose cotransporter 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	596 aa 64.3 kDa	No	>9
SLC5A10-003 ENSP00000379005 ENST00000395643	A0PJK1 [Direct mapping] Sodium/glucose cotransporter 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	569 aa 61.6 kDa	No	>9
SLC5A10-004 ENSP00000324346 ENST00000317977	A0PJK1 [Direct mapping] Sodium/glucose cotransporter 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	566 aa 61.6 kDa	No	>9
SLC5A10-201 ENSP00000401875 ENST00000417251	A0PJK1 [Direct mapping] Sodium/glucose cotransporter 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	560 aa 60.6 kDa	No	>9

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