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AK5

GENERAL INFORMATION

Gene name

 AK5

Gene description

 Adenylate kinase 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, glioma, melanoma, pancreatic cancer, prostate cancer, testis cancer)
HPA (cell line):Cell line enhanced (ASC TERT1, BJ, LHCN-M2, U-2 OS)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA019128 , HPA057255
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (favourable).
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, glioma, melanoma, pancreatic cancer, prostate cancer, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA019128
HPA057255

GENE INFORMATION

Gene name

 AK5

Synonyms

Description

 Adenylate kinase 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 77282051 - 77559969

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154027 (version 83.38)

Entrez gene

 26289

UniProt

 Q9Y6K8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6K8

Antibodypedia

 AK5 antibodies

PROTEIN BROWSER
AK5-001
AK5-002
AK5-005
AK5-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK5-001
ENSP00000346577
ENST00000354567
Q9Y6K8 [Direct mapping]
Adenylate kinase isoenzyme 5
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0006173 [dADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0009220 [pyrimidine ribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046034 [ATP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
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 562 aa
63.3 kDa 		No 0
AK5-002
ENSP00000341430
ENST00000344720
Q9Y6K8 [Direct mapping]
Adenylate kinase isoenzyme 5
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0006173 [dADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0009220 [pyrimidine ribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046034 [ATP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
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 536 aa
60.3 kDa 		No 0
AK5-005
ENSP00000434409
ENST00000478407
E9PQQ8 [Direct mapping]
Adenylate kinase isoenzyme 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
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 176 aa
20 kDa 		No 0
AK5-009
ENSP00000433915
ENST00000478255
E9PIS7 [Direct mapping]
Adenylate kinase isoenzyme 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
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 77 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.