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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AK5
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AK5

Gene description

Adenylate kinase 5

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (breast cancer, glioma, melanoma, pancreatic cancer, prostate cancer, testis cancer)
HPA (cell line):Cell line enhanced (ASC TERT1, BJ, LHCN-M2, U-2 OS)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 2 antibodies.
HPA019128 , HPA057255
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in prostate cancer (favourable).
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (breast cancer, glioma, melanoma, pancreatic cancer, prostate cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA019128
HPA057255

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Tumour cells displayed moderate cytoplasmic positivity. A few cases of colorectal and prostate cancers showed strong immunoreactivity. Lymphoma, renal and urothelial cancers were weakly stained in several cases.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Squamous and basal cell carcinomas, gliomas, adenocarcinomas of cervix, several colorectal and urothelial cancers along with a few stomach and pancreatic cancers displayed moderate to strong cytoplasmic and/or membranous positivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

AK5

Synonyms

Description

Adenylate kinase 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

77282051 - 77559969

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154027 (version 83.38)

Entrez gene

26289

UniProt

Q9Y6K8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6K8

Antibodypedia

AK5 antibodies

PROTEIN BROWSER

AK5-001
AK5-002
AK5-005
AK5-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AK5-001
ENSP00000346577
ENST00000354567
Q9Y6K8 [Direct mapping]
Adenylate kinase isoenzyme 5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0006173 [dADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0009220 [pyrimidine ribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046034 [ATP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
562 aa
63.3 kDa
No 0
AK5-002
ENSP00000341430
ENST00000344720
Q9Y6K8 [Direct mapping]
Adenylate kinase isoenzyme 5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0006173 [dADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0009220 [pyrimidine ribonucleotide biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046034 [ATP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
536 aa
60.3 kDa
No 0
AK5-005
ENSP00000434409
ENST00000478407
E9PQQ8 [Direct mapping]
Adenylate kinase isoenzyme 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
176 aa
20 kDa
No 0
AK5-009
ENSP00000433915
ENST00000478255
E9PIS7 [Direct mapping]
Adenylate kinase isoenzyme 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
77 aa
8.7 kDa
No 0

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