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NRGN

GENERAL INFORMATION

Gene name

 NRGN

Gene description

 Neurogranin (protein kinase C substrate, RC3)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, PC-3)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA038171 , CAB006908
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038171
CAB006908

GENE INFORMATION

Gene name

 NRGN (HGNC Symbol)

Synonyms

 RC3

Description

 Neurogranin (protein kinase C substrate, RC3) (HGNC Symbol)

Entrez gene summary

 Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 124739846 - 124747210

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154146 (version 83.38)

Entrez gene

 4900

UniProt

 Q92686 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92686

Antibodypedia

 NRGN antibodies

PROTEIN BROWSER
NRGN-001
NRGN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRGN-001
ENSP00000284292
ENST00000284292
Q92686 [Direct mapping]
Neurogranin NEUG(55-78)
A0A024R3M7 [Target identity:100%; Query identity:100%]
Neurogranin (Protein kinase C substrate, RC3), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008306 [associative learning]
GO:0012510 [trans-Golgi network transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0021537 [telencephalon development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031966 [mitochondrial membrane]
GO:0035556 [intracellular signal transduction]
GO:0043025 [neuronal cell body]
GO:0044327 [dendritic spine head]
GO:0045202 [synapse]
GO:0070300 [phosphatidic acid binding]
GO:1900273 [positive regulation of long-term synaptic potentiation]
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 78 aa
7.6 kDa 		No 0
NRGN-002
ENSP00000399591
ENST00000412681
Q92686 [Direct mapping]
Neurogranin NEUG(55-78)
A0A024R3M7 [Target identity:100%; Query identity:100%]
Neurogranin (Protein kinase C substrate, RC3), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0035556 [intracellular signal transduction]
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 78 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.