Tissue expression of CERS3 - Summary - The Human Protein Atlas

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CERS3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CERS3
Gene description	Ceramide synthase 3
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (esophagus, skin, testis, tonsil)
GTEx:	Tissue enhanced (esophagus, skin, vagina)
FANTOM5:	Group enriched (cervix, uterine, esophagus, testis, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA006092 , HPA024356
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, skin, testis, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, skin, vagina)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cervix, uterine, esophagus, testis, tonsil)

GENE INFORMATION
Gene name	CERS3 (HGNC Symbol)
Synonyms	LASS3, MGC27091
Description	Ceramide synthase 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Chromosome	15
Cytoband	q26.3
Chromosome location (bp)	100400395 - 100544995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154227 (version 83.38)
Entrez gene	204219
UniProt	Q8IU89 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IU89
Antibodypedia	CERS3 antibodies

PROTEIN BROWSER

CERS3-001	CERS3-002	CERS3-004	CERS3-005	CERS3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CERS3-001 ENSP00000284382 ENST00000284382	Q8IU89 [Direct mapping] Ceramide synthase 3 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0030216 [keratinocyte differentiation] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	383 aa 46.3 kDa	No	7
CERS3-002 ENSP00000377672 ENST00000394113	Q8IU89 [Direct mapping] Ceramide synthase 3 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0030216 [keratinocyte differentiation] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	383 aa 46.3 kDa	No	7
CERS3-004 ENSP00000453816 ENST00000558884	H0YN05 [Direct mapping] Ceramide synthase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0050291 [sphingosine N-acyltransferase activity] Show all	162 aa 19.7 kDa	No	2
CERS3-005 ENSP00000437640 ENST00000538112	Q8IU89 [Direct mapping] Ceramide synthase 3 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0030216 [keratinocyte differentiation] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	383 aa 46.3 kDa	No	7
CERS3-006 ENSP00000453598 ENST00000559639	H0YMG6 [Direct mapping] Ceramide synthase 3 Show all	Predicted intracellular proteins Show all	GO:0050291 [sphingosine N-acyltransferase activity] Show all	15 aa 2.2 kDa	No	0

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The Human Protein Atlas

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