Expression of ABCA10 in cancer - Summary - The Human Protein Atlas

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ABCA10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABCA10
Gene description	ATP-binding cassette, sub-family A (ABC1), member 10
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HUVEC TERT2, RT4, U-2197)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA014535
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014535

GENE INFORMATION
Gene name	ABCA10 (HGNC Symbol)
Synonyms	EST698739
Description	ATP-binding cassette, sub-family A (ABC1), member 10 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q24.3
Chromosome location (bp)	69147214 - 69244846
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154263 (version 83.38)
Entrez gene	10349
UniProt	Q8WWZ4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WWZ4
Antibodypedia	ABCA10 antibodies

PROTEIN BROWSER

ABCA10-001	ABCA10-010	ABCA10-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCA10-001 ENSP00000269081 ENST00000269081	Q8WWZ4 [Direct mapping] ATP-binding cassette sub-family A member 10 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	1543 aa 175.8 kDa	No	>9
ABCA10-010 ENSP00000466506 ENST00000521538	K7EMH5 [Direct mapping] ATP-binding cassette sub-family A member 10 Show all	Predicted intracellular proteins Show all	GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	76 aa 8.4 kDa	No	0
ABCA10-011 ENSP00000468351 ENST00000522787	K7ERP5 [Direct mapping] ATP-binding cassette sub-family A member 10 Show all	Predicted intracellular proteins Show all	GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	45 aa 5.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.