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MIA3

GENERAL INFORMATION

Gene name

 MIA3

Gene description

 Melanoma inhibitory activity family, member 3

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
HPA055922 , HPA056816
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055922
HPA056816

GENE INFORMATION

Gene name

 MIA3 (HGNC Symbol)

Synonyms

 FLJ39207, KIAA0268, TANGO, UNQ6077

Description

 Melanoma inhibitory activity family, member 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 222618086 - 222668012

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154305 (version 83.38)

Entrez gene

 375056

UniProt

 Q5JRA6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JRA6

Antibodypedia

 MIA3 antibodies

PROTEIN BROWSER
MIA3-001
MIA3-002
MIA3-003
MIA3-005
MIA3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIA3-001
ENSP00000340900
ENST00000344922
Q5JRA6 [Direct mapping]
Melanoma inhibitory activity protein 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002063 [chondrocyte development]
GO:0002687 [positive regulation of leukocyte migration]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006887 [exocytosis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007162 [negative regulation of cell adhesion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030199 [collagen fibril organization]
GO:0030336 [negative regulation of cell migration]
GO:0030501 [positive regulation of bone mineralization]
GO:0042060 [wound healing]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
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 1907 aa
213.7 kDa 		Yes 2
MIA3-002
ENSP00000341348
ENST00000344507
Q5JRA6 [Direct mapping]
Melanoma inhibitory activity protein 3
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002687 [positive regulation of leukocyte migration]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006887 [exocytosis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007162 [negative regulation of cell adhesion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030336 [negative regulation of cell migration]
GO:0042060 [wound healing]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
Show all
 500 aa
56.6 kDa 		Yes 0
MIA3-003
ENSP00000355062
ENST00000354906
A0A0A0MRH6 [Direct mapping]
Melanoma inhibitory activity protein 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005789 [endoplasmic reticulum membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
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 1016 aa
114 kDa 		No 1
MIA3-005
ENSP00000345866
ENST00000340535
Q5JRA6 [Direct mapping]
Melanoma inhibitory activity protein 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002687 [positive regulation of leukocyte migration]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006887 [exocytosis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007162 [negative regulation of cell adhesion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030336 [negative regulation of cell migration]
GO:0042060 [wound healing]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
Show all
 785 aa
87.4 kDa 		No 2
MIA3-006
ENSP00000396598
ENST00000450260
H7C0T4 [Direct mapping]
Melanoma inhibitory activity protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0015031 [protein transport]
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 107 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.