Tissue expression of NEIL2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NEIL2
Gene description	Nei-like DNA glycosylase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NEIL2 (HGNC Symbol)
Synonyms	FLJ31644, MGC2832, MGC4505, NEH2
Description	Nei-like DNA glycosylase 2 (HGNC Symbol)
Entrez gene summary	NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	11769639 - 11787346
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154328 (version 83.38)
Entrez gene	252969
UniProt	Q969S2 (UniProt - Evidence at protein level)
neXtProt	NX_Q969S2
Antibodypedia	NEIL2 antibodies

PROTEIN BROWSER

NEIL2-001	NEIL2-002	NEIL2-003	NEIL2-004	NEIL2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEIL2-001 ENSP00000284503 ENST00000284503	Q969S2 [Direct mapping] Endonuclease 8-like 2 A0A024R361 [Target identity:100%; Query identity:100%] Nei like 2 (E. coli), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005876 [spindle microtubule] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0045008 [depyrimidination] Show all	332 aa 36.8 kDa	No	0
NEIL2-002 ENSP00000435657 ENST00000528323	Q969S2 [Direct mapping] Endonuclease 8-like 2 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0045008 [depyrimidination] Show all	216 aa 24.1 kDa	No	0
NEIL2-003 ENSP00000397538 ENST00000455213	Q969S2 [Direct mapping] Endonuclease 8-like 2 A0A024R361 [Target identity:100%; Query identity:100%] Nei like 2 (E. coli), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0045008 [depyrimidination] Show all	332 aa 36.8 kDa	No	0
NEIL2-004 ENSP00000394023 ENST00000436750	Q969S2 [Direct mapping] Endonuclease 8-like 2 A0A024R361 [Target identity:100%; Query identity:100%] Nei like 2 (E. coli), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0045008 [depyrimidination] Show all	332 aa 36.8 kDa	No	0
NEIL2-007 ENSP00000384070 ENST00000403422	Q969S2 [Direct mapping] Endonuclease 8-like 2 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0045008 [depyrimidination] Show all	271 aa 29.9 kDa	No	0