Expression of ENAH in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ENAH
Gene description	Enabled homolog (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including breast myoepithelial cells, basal prostate epithelium and membranous expression in pancreatic acinar duct epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA028448 , HPA028696
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA028448	HPA028696

GENE INFORMATION
Gene name	ENAH (HGNC Symbol)
Synonyms	FLJ10773, MENA, NDPP1
Description	Enabled homolog (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q42.12
Chromosome location (bp)	225486835 - 225653142
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154380 (version 83.38)
Entrez gene	55740
UniProt	Q8N8S7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8S7
Antibodypedia	ENAH antibodies

PROTEIN BROWSER

ENAH-001	ENAH-002	ENAH-006	ENAH-007	ENAH-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENAH-001 ENSP00000355808 ENST00000366843	Q8N8S7 [Direct mapping] Protein enabled homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007411 [axon guidance] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030175 [filopodium] GO:0045202 [synapse] GO:0046907 [intracellular transport] GO:0050699 [WW domain binding] GO:0050852 [T cell receptor signaling pathway] Show all	570 aa 63.9 kDa	No	0
ENAH-002 ENSP00000284563 ENST00000284563	A0A075B6E5 [Direct mapping] Protein enabled homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 24.9 kDa	No	0
ENAH-006 ENSP00000355809 ENST00000366844	Q8N8S7 [Direct mapping] Protein enabled homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0001843 [neural tube closure] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007411 [axon guidance] GO:0008154 [actin polymerization or depolymerization] GO:0017124 [SH3 domain binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] GO:0030175 [filopodium] GO:0045202 [synapse] GO:0046907 [intracellular transport] GO:0050699 [WW domain binding] GO:0050852 [T cell receptor signaling pathway] Show all	591 aa 66.5 kDa	No	0
ENAH-007 ENSP00000489106 ENST00000497899		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		242 aa 29.8 kDa	No	0
ENAH-011 ENSP00000489607 ENST00000635051		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		802 aa 87.4 kDa	No	0