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CCSAP

GENERAL INFORMATION

Gene name

 CCSAP

Gene description

 Centriole, cilia and spindle-associated protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA028402 , HPA043443
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028402
HPA043443

GENE INFORMATION

Gene name

 CCSAP (HGNC Symbol)

Synonyms

 C1orf96, CSAP, FLJ41471

Description

 Centriole, cilia and spindle-associated protein (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q42.13

Chromosome location (bp)

 229321005 - 229343294

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154429 (version 83.38)

Entrez gene

 126731

UniProt

 Q6IQ19 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IQ19

Antibodypedia

 CCSAP antibodies

PROTEIN BROWSER
CCSAP-001
CCSAP-003
CCSAP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCSAP-001
ENSP00000355648
ENST00000366687
Q6IQ19 [Direct mapping]
Centriole, cilia and spindle-associated protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0007275 [multicellular organismal development]
GO:0030424 [axon]
GO:0035869 [ciliary transition zone]
GO:0036064 [ciliary basal body]
GO:0045995 [regulation of embryonic development]
GO:0060296 [regulation of cilium beat frequency involved in ciliary motility]
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 270 aa
30.2 kDa 		No 0
CCSAP-003
ENSP00000355647
ENST00000366686
Q6IQ19 [Direct mapping]
Centriole, cilia and spindle-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0007275 [multicellular organismal development]
GO:0030424 [axon]
GO:0035869 [ciliary transition zone]
GO:0036064 [ciliary basal body]
GO:0045995 [regulation of embryonic development]
GO:0060296 [regulation of cilium beat frequency involved in ciliary motility]
Show all
 156 aa
17.8 kDa 		No 0
CCSAP-201
ENSP00000284617
ENST00000284617
Q6IQ19 [Direct mapping]
Centriole, cilia and spindle-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0007275 [multicellular organismal development]
GO:0030424 [axon]
GO:0035869 [ciliary transition zone]
GO:0036064 [ciliary basal body]
GO:0045995 [regulation of embryonic development]
GO:0060296 [regulation of cilium beat frequency involved in ciliary motility]
Show all
 270 aa
30.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.