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ATP5G3

GENERAL INFORMATION

Gene name

 ATP5G3

Gene description

 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ATP5G3

Synonyms

Description

 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 175176258 - 175184607

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000154518 (version 83.38)

Entrez gene

 518

UniProt

 P48201 (UniProt - Evidence at transcript level)

neXtProt

 NX_P48201

Antibodypedia

 ATP5G3 antibodies

PROTEIN BROWSER
ATP5G3-001
ATP5G3-002
ATP5G3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5G3-001
ENSP00000284727
ENST00000284727
P48201 [Direct mapping]
ATP synthase F(0) complex subunit C3, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0007568 [aging]
GO:0008289 [lipid binding]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0045471 [response to ethanol]
Show all
 142 aa
14.7 kDa 		No 2
ATP5G3-002
ENSP00000387317
ENST00000409194
P48201 [Direct mapping]
ATP synthase F(0) complex subunit C3, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005741 [mitochondrial outer membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0008289 [lipid binding]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)]
Show all
 142 aa
14.7 kDa 		No 2
ATP5G3-003
ENSP00000376324
ENST00000392541
P48201 [Direct mapping]
ATP synthase F(0) complex subunit C3, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005741 [mitochondrial outer membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0008289 [lipid binding]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)]
Show all
 142 aa
14.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.