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TCEB1

GENERAL INFORMATION

Gene name

 TCEB1

Gene description

 Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TCEB1 (HGNC Symbol)

Synonyms

 SIII

Description

 Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (HGNC Symbol)

Entrez gene summary

 This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Chromosome

 8

Cytoband

 q21.11

Chromosome location (bp)

 73939169 - 73972287

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154582 (version 83.38)

Entrez gene

 6921

UniProt

 Q15369 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15369

Antibodypedia

 TCEB1 antibodies

PROTEIN BROWSER
TCEB1-001
TCEB1-003
TCEB1-004
TCEB1-005
TCEB1-006
TCEB1-007
TCEB1-008
TCEB1-009
TCEB1-010
TCEB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCEB1-001
ENSP00000428171
ENST00000520242
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0
TCEB1-003
ENSP00000430224
ENST00000520210
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 96 aa
10.8 kDa 		No 0
TCEB1-004
ENSP00000428334
ENST00000518127
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0
TCEB1-005
ENSP00000473408
ENST00000602840
R4GMY8 [Direct mapping]
Transcription elongation factor B polypeptide 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0070449 [elongin complex]
Show all
 65 aa
7 kDa 		No 0
TCEB1-006
ENSP00000429596
ENST00000519487
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0
TCEB1-007
ENSP00000284811
ENST00000284811
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0
TCEB1-008
ENSP00000428074
ENST00000523815
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0
TCEB1-009
ENSP00000429789
ENST00000519082
E5RHG8 [Direct mapping]
Transcription elongation factor B polypeptide 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0070449 [elongin complex]
Show all
 89 aa
10 kDa 		No 0
TCEB1-010
ENSP00000429906
ENST00000522337
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0
TCEB1-201
ENSP00000478121
ENST00000622804
Q15369 [Direct mapping]
Transcription elongation factor B polypeptide 1
A0A024R7Y5 [Target identity:100%; Query identity:100%]
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070449 [elongin complex]
GO:0071456 [cellular response to hypoxia]
Show all
 112 aa
12.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.