Fields »
ABOUT
HELP
BLOG
LY96

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 LY96

Gene description

 Lymphocyte antigen 96

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (Karpas-707, U-87 MG)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA053060
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, U-87 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053060 A-431 Vesicles
HPA053060 U-2 OS Vesicles
HPA053060 U-251 MG Vesicles

GENE INFORMATION

Gene name

 LY96 (HGNC Symbol)

Synonyms

 MD-2

Description

 Lymphocyte antigen 96 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Chromosome

 8

Cytoband

 q21.11

Chromosome location (bp)

 73991352 - 74029087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154589 (version 83.38)

Entrez gene

 23643

UniProt

 Q9Y6Y9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6Y9

Antibodypedia

 LY96 antibodies

PROTEIN BROWSER
LY96-001
LY96-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LY96-001
ENSP00000284818
ENST00000284818
Q9Y6Y9 [Direct mapping]
Lymphocyte antigen 96
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001875 [lipopolysaccharide receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0010008 [endosome membrane]
GO:0012501 [programmed cell death]
GO:0015026 [coreceptor activity]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032497 [detection of lipopolysaccharide]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 160 aa
18.5 kDa 		Yes 0
LY96-003
ENSP00000430533
ENST00000518893
Q9Y6Y9 [Direct mapping]
Lymphocyte antigen 96
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001875 [lipopolysaccharide receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0010008 [endosome membrane]
GO:0012501 [programmed cell death]
GO:0015026 [coreceptor activity]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032497 [detection of lipopolysaccharide]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 130 aa
14.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.