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CXADR

GENERAL INFORMATION

Gene name

 CXADR

Gene description

 Coxsackie virus and adenovirus receptor

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2, NTERA-2, RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA003342 , HPA030411 , HPA030412 , CAB005103
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA003342
HPA030411
HPA030412
CAB005103

GENE INFORMATION

Gene name

 CXADR (HGNC Symbol)

Synonyms

 CAR

Description

 Coxsackie virus and adenovirus receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

Chromosome

 21

Cytoband

 q21.1

Chromosome location (bp)

 17512382 - 17593579

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154639 (version 83.38)

Entrez gene

 1525

UniProt

 P78310 (UniProt - Evidence at protein level)

neXtProt

 NX_P78310

Antibodypedia

 CXADR antibodies

PROTEIN BROWSER
CXADR-001
CXADR-002
CXADR-003
CXADR-004
CXADR-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXADR-001
ENSP00000284878
ENST00000284878
P78310 [Direct mapping]
Coxsackievirus and adenovirus receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0007005 [mitochondrion organization]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0008354 [germ cell migration]
GO:0010669 [epithelial structure maintenance]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030593 [neutrophil chemotaxis]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0045216 [cell-cell junction organization]
GO:0046629 [gamma-delta T cell activation]
GO:0046718 [viral entry into host cell]
GO:0048739 [cardiac muscle fiber development]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0051607 [defense response to virus]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0070633 [transepithelial transport]
GO:0071253 [connexin binding]
GO:0086067 [AV node cell to bundle of His cell communication]
GO:0086072 [AV node cell-bundle of His cell adhesion involved in cell communication]
GO:0098904 [regulation of AV node cell action potential]
Show all
 365 aa
40 kDa 		Yes 1
CXADR-002
ENSP00000383033
ENST00000400169
P78310 [Direct mapping]
Coxsackievirus and adenovirus receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0007005 [mitochondrion organization]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0008354 [germ cell migration]
GO:0010669 [epithelial structure maintenance]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030593 [neutrophil chemotaxis]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0045216 [cell-cell junction organization]
GO:0046629 [gamma-delta T cell activation]
GO:0046718 [viral entry into host cell]
GO:0048739 [cardiac muscle fiber development]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0051607 [defense response to virus]
GO:0070633 [transepithelial transport]
GO:0071253 [connexin binding]
GO:0086067 [AV node cell to bundle of His cell communication]
Show all
 352 aa
38.9 kDa 		Yes 1
CXADR-003
ENSP00000383030
ENST00000400166
P78310 [Direct mapping]
Coxsackievirus and adenovirus receptor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0007005 [mitochondrion organization]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0008354 [germ cell migration]
GO:0010669 [epithelial structure maintenance]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030593 [neutrophil chemotaxis]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0045216 [cell-cell junction organization]
GO:0046629 [gamma-delta T cell activation]
GO:0046718 [viral entry into host cell]
GO:0048739 [cardiac muscle fiber development]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0051607 [defense response to virus]
GO:0070633 [transepithelial transport]
GO:0071253 [connexin binding]
GO:0086067 [AV node cell to bundle of His cell communication]
Show all
 252 aa
28.2 kDa 		Yes 0
CXADR-004
ENSP00000383029
ENST00000400165
P78310 [Direct mapping]
Coxsackievirus and adenovirus receptor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0007005 [mitochondrion organization]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0008354 [germ cell migration]
GO:0010669 [epithelial structure maintenance]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030593 [neutrophil chemotaxis]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0045216 [cell-cell junction organization]
GO:0046629 [gamma-delta T cell activation]
GO:0046718 [viral entry into host cell]
GO:0048739 [cardiac muscle fiber development]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0051607 [defense response to virus]
GO:0070633 [transepithelial transport]
GO:0071253 [connexin binding]
GO:0086067 [AV node cell to bundle of His cell communication]
Show all
 200 aa
22.4 kDa 		Yes 0
CXADR-005
ENSP00000348620
ENST00000356275
P78310 [Direct mapping]
Coxsackievirus and adenovirus receptor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0007005 [mitochondrion organization]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008013 [beta-catenin binding]
GO:0008354 [germ cell migration]
GO:0010669 [epithelial structure maintenance]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030593 [neutrophil chemotaxis]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0045216 [cell-cell junction organization]
GO:0046629 [gamma-delta T cell activation]
GO:0046718 [viral entry into host cell]
GO:0048739 [cardiac muscle fiber development]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0051607 [defense response to virus]
GO:0070633 [transepithelial transport]
GO:0071253 [connexin binding]
GO:0086067 [AV node cell to bundle of His cell communication]
Show all
 89 aa
10 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.