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RABGEF1

GENERAL INFORMATION

Gene name

 RABGEF1

Gene description

 RAB guanine nucleotide exchange factor (GEF) 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and renal cancer (favourable).
Glioma p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RABGEF1 (HGNC Symbol)

Synonyms

 rabex-5, RABEX5

Description

 RAB guanine nucleotide exchange factor (GEF) 1 (HGNC Symbol)

Entrez gene summary

 RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]

Chromosome

 7

Cytoband

 q11.21

Chromosome location (bp)

 66682164 - 66811464

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154710 (version 83.38)

Entrez gene

 27342

UniProt

 Q9UJ41 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJ41

Antibodypedia

 RABGEF1 antibodies

PROTEIN BROWSER
RABGEF1-001
RABGEF1-002
RABGEF1-003
RABGEF1-005
RABGEF1-201
RABGEF1-202
RABGEF1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RABGEF1-001
ENSP00000284957
ENST00000284957
Q9UJ41 [Direct mapping]
Rab5 GDP/GTP exchange factor
A0A024RDL6 [Target identity:100%; Query identity:100%]
RAB guanine nucleotide exchange factor (GEF) 1, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0006612 [protein targeting to membrane]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0017137 [Rab GTPase binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0055037 [recycling endosome]
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 491 aa
56.9 kDa 		No 0
RABGEF1-002
ENSP00000415815
ENST00000450873
Q9UJ41 [Direct mapping]
Rab5 GDP/GTP exchange factor
A0A024RDL6 [Target identity:100%; Query identity:100%]
RAB guanine nucleotide exchange factor (GEF) 1, isoform CRA_b
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0006612 [protein targeting to membrane]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0017137 [Rab GTPase binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0055037 [recycling endosome]
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 491 aa
56.9 kDa 		No 0
RABGEF1-003
ENSP00000403429
ENST00000439720
E9PFK9 [Direct mapping]
Rab5 GDP/GTP exchange factor
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
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 504 aa
58.4 kDa 		No 0
RABGEF1-005
ENSP00000415503
ENST00000442563
C9JDA2 [Direct mapping]
Rab5 GDP/GTP exchange factor
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
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 45 aa
5.3 kDa 		No 0
RABGEF1-201
ENSP00000370208
ENST00000380828
Q9UJ41 [Direct mapping]
Rab5 GDP/GTP exchange factor
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Predicted intracellular proteins
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GO:0001933 [negative regulation of protein phosphorylation]
GO:0002686 [negative regulation of leukocyte migration]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0006612 [protein targeting to membrane]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0017137 [Rab GTPase binding]
GO:0031982 [vesicle]
GO:0033004 [negative regulation of mast cell activation]
GO:0043305 [negative regulation of mast cell degranulation]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0050728 [negative regulation of inflammatory response]
GO:0055037 [recycling endosome]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:1900235 [negative regulation of Kit signaling pathway]
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 505 aa
58.5 kDa 		No 0
RABGEF1-202
ENSP00000390480
ENST00000437078
A0A0A0MSJ3 [Direct mapping]
RAB guanine nucleotide exchange factor (GEF) 1, isoform CRA_c; Rab5 GDP/GTP exchange factor
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Predicted intracellular proteins
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 299 aa
34.4 kDa 		No 0
RABGEF1-203
ENSP00000421124
ENST00000510829
Q3HKR1 [Direct mapping]
RAP1 short isoform; Rab5 GDP/GTP exchange factor
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
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 407 aa
47 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.