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PPP4R1

GENERAL INFORMATION

Gene name

 PPP4R1

Gene description

 Protein phosphatase 4, regulatory subunit 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA040905 , HPA041089
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040905
HPA041089

GENE INFORMATION

Gene name

 PPP4R1 (HGNC Symbol)

Synonyms

 PP4R1

Description

 Protein phosphatase 4, regulatory subunit 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Chromosome

 18

Cytoband

 p11.22

Chromosome location (bp)

 9546791 - 9615240

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154845 (version 83.38)

Entrez gene

 9989

UniProt

 Q8TF05 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TF05

Antibodypedia

 PPP4R1 antibodies

PROTEIN BROWSER
PPP4R1-001
PPP4R1-002
PPP4R1-006
PPP4R1-007
PPP4R1-008
PPP4R1-011
PPP4R1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP4R1-001
ENSP00000383402
ENST00000400556
Q8TF05 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 950 aa
107 kDa 		No 0
PPP4R1-002
ENSP00000383401
ENST00000400555
Q8TF05 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 933 aa
105.2 kDa 		No 0
PPP4R1-006
ENSP00000463345
ENST00000580745
J3QL26 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 135 aa
15.5 kDa 		No 0
PPP4R1-007
ENSP00000463909
ENST00000582240
J3QQV0 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 190 aa
21 kDa 		No 0
PPP4R1-008
ENSP00000463459
ENST00000584074
J3QLA6 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 151 aa
17.2 kDa 		No 0
PPP4R1-011
ENSP00000462399
ENST00000581250
J3KSB0 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 143 aa
16.3 kDa 		No 0
PPP4R1-012
ENSP00000462161
ENST00000581835
J3KRU1 [Direct mapping]
Serine/threonine-protein phosphatase 4 regulatory subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
GO:0030289 [protein phosphatase 4 complex]
GO:0030362 [protein phosphatase type 4 regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 97 aa
11.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.