Expression of PIEZO2 in cancer - Summary - The Human Protein Atlas

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PIEZO2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIEZO2
Gene description	Piezo-type mechanosensitive ion channel component 2
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, HeLa, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA015986 , HPA031974 , HPA040616
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015986	HPA031974	HPA040616

GENE INFORMATION
Gene name	PIEZO2 (HGNC Symbol)
Synonyms	C18orf30, C18orf58, FAM38B, FAM38B2, FLJ23144, FLJ23403, FLJ34907, HsT748, HsT771
Description	Piezo-type mechanosensitive ion channel component 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Chromosome	18
Cytoband
Chromosome location (bp)	10666483 - 11148762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154864 (version 83.38)
Entrez gene	63895
UniProt	Q9H5I5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H5I5
Antibodypedia	PIEZO2 antibodies

PROTEIN BROWSER

PIEZO2-003	PIEZO2-004	PIEZO2-005	PIEZO2-006	PIEZO2-007	PIEZO2-010	PIEZO2-011	PIEZO2-013	PIEZO2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIEZO2-003 ENSP00000421377 ENST00000503781	Q9H5I5 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005261 [cation channel activity] GO:0006812 [cation transport] GO:0008381 [mechanically-gated ion channel activity] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0050974 [detection of mechanical stimulus involved in sensory perception] GO:0098655 [cation transmembrane transport] Show all	2752 aa 318.1 kDa	Yes	>9
PIEZO2-004 ENSP00000462560 ENST00000583325	J3KSM7 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	192 aa 22.9 kDa	No	4
PIEZO2-005 ENSP00000477311 ENST00000579949	V9GZ18 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	153 aa 17.6 kDa	No	0
PIEZO2-006 ENSP00000463094 ENST00000580640	Q9H5I5 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] GO:0050974 [detection of mechanical stimulus involved in sensory perception] Show all	2777 aa 320.9 kDa	Yes	>9
PIEZO2-007 ENSP00000303316 ENST00000302079	Q9H5I5 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] GO:0050974 [detection of mechanical stimulus involved in sensory perception] Show all	2689 aa 311.1 kDa	Yes	>9
PIEZO2-010 ENSP00000462187 ENST00000582937	J3KRW1 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.3 kDa	No	0
PIEZO2-011 ENSP00000443129 ENST00000538948	Q9H5I5 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] GO:0050974 [detection of mechanical stimulus involved in sensory perception] Show all	709 aa 80.8 kDa	No	6
PIEZO2-013 ENSP00000463589 ENST00000579112	J3QLJ9 [Direct mapping] Piezo-type mechanosensitive ion channel component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	178 aa 20.5 kDa	No	1
PIEZO2-201 ENSP00000372900 ENST00000383408	E7EVM7 [Direct mapping] Piezo-type mechanosensitive ion channel component Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008381 [mechanically-gated ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	2703 aa 312.6 kDa	No	>9

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The Human Protein Atlas

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