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EME1

GENERAL INFORMATION

Gene name

 EME1

Gene description

 Essential meiotic structure-specific endonuclease 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (epididymis, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
CAB016127
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016127

GENE INFORMATION

Gene name

 EME1 (HGNC Symbol)

Synonyms

 FLJ31364, MMS4L, SLX2A

Description

 Essential meiotic structure-specific endonuclease 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Chromosome

 17

Cytoband

 q21.33

Chromosome location (bp)

 50373220 - 50381483

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154920 (version 83.38)

Entrez gene

 146956

UniProt

 Q96AY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96AY2

Antibodypedia

 EME1 antibodies

PROTEIN BROWSER
EME1-001
EME1-002
EME1-007
EME1-013
EME1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EME1-001
ENSP00000339897
ENST00000338165
Q96AY2 [Direct mapping]
Crossover junction endonuclease EME1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0046872 [metal ion binding]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 570 aa
63.3 kDa 		No 0
EME1-002
ENSP00000421700
ENST00000511648
Q96AY2 [Direct mapping]
Crossover junction endonuclease EME1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0046872 [metal ion binding]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 583 aa
64.8 kDa 		No 0
EME1-007
ENSP00000425567
ENST00000510246
H0Y9Z4 [Direct mapping]
Crossover junction endonuclease EME1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 337 aa
37.1 kDa 		No 0
EME1-013
ENSP00000423029
ENST00000511519
F8W714 [Direct mapping]
Crossover junction endonuclease EME1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 171 aa
18.5 kDa 		No 0
EME1-201
ENSP00000376952
ENST00000393271
Q96AY2 [Direct mapping]
Crossover junction endonuclease EME1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0046872 [metal ion binding]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 583 aa
64.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.