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EPHB1

GENERAL INFORMATION

Gene name

 EPHB1

Gene description

 EPH receptor B1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, testis)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in the CNS and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA067740
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 EPHB1 (HGNC Symbol)

Synonyms

 EPHT2, Hek6

Description

 EPH receptor B1 (HGNC Symbol)

Entrez gene summary

 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q22.2

Chromosome location (bp)

 134597801 - 135260467

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154928 (version 83.38)

Entrez gene

 2047

UniProt

 P54762 (UniProt - Evidence at protein level)

neXtProt

 NX_P54762

Antibodypedia

 EPHB1 antibodies

PROTEIN BROWSER
EPHB1-004
EPHB1-005
EPHB1-006
EPHB1-011
EPHB1-012
EPHB1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHB1-004
ENSP00000417435
ENST00000460895
C9JB88 [Direct mapping]
Ephrin type-B receptor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0048013 [ephrin receptor signaling pathway]
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 113 aa
13 kDa 		No 0
EPHB1-005
ENSP00000381097
ENST00000398015
P54762 [Direct mapping]
Ephrin type-B receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001771 [immunological synapse formation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021952 [central nervous system projection neuron axonogenesis]
GO:0022008 [neurogenesis]
GO:0030010 [establishment of cell polarity]
GO:0030425 [dendrite]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031589 [cell-substrate adhesion]
GO:0031901 [early endosome membrane]
GO:0046328 [regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051965 [positive regulation of synapse assembly]
GO:0060326 [cell chemotaxis]
GO:0060996 [dendritic spine development]
GO:0060997 [dendritic spine morphogenesis]
GO:0061351 [neural precursor cell proliferation]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:1901214 [regulation of neuron death]
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 984 aa
109.9 kDa 		Yes 1
EPHB1-006
ENSP00000419574
ENST00000493838
P54762 [Direct mapping]
Ephrin type-B receptor 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007411 [axon guidance]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021952 [central nervous system projection neuron axonogenesis]
GO:0022008 [neurogenesis]
GO:0030010 [establishment of cell polarity]
GO:0030425 [dendrite]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031589 [cell-substrate adhesion]
GO:0031901 [early endosome membrane]
GO:0046328 [regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051965 [positive regulation of synapse assembly]
GO:0060326 [cell chemotaxis]
GO:0060996 [dendritic spine development]
GO:0060997 [dendritic spine morphogenesis]
GO:0061351 [neural precursor cell proliferation]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:1901214 [regulation of neuron death]
Show all
 545 aa
61.4 kDa 		No 1
EPHB1-011
ENSP00000418352
ENST00000474732
C9J6S4 [Direct mapping]
Ephrin type-B receptor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0048013 [ephrin receptor signaling pathway]
Show all
 150 aa
17.1 kDa 		No 0
EPHB1-012
ENSP00000419688
ENST00000497173
C9K090 [Direct mapping]
Ephrin type-B receptor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0048013 [ephrin receptor signaling pathway]
Show all
 42 aa
4.7 kDa 		No 0
EPHB1-013
ENSP00000417216
ENST00000473867
C9J466 [Direct mapping]
Ephrin type-B receptor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0048013 [ephrin receptor signaling pathway]
Show all
 102 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.