Cell atlas - FBXL18 - The Human Protein Atlas

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FBXL18

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FBXL18
Gene description	F-box and leucine-rich repeat protein 18
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036049
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036049	A-431	Nucleoplasm	Spatial
	HPA036049	A-431	Cytosol	Spatial
	HPA036049	U-2 OS	Nucleoplasm	Spatial
	HPA036049	U-2 OS	Cytosol	Spatial
	HPA036049	U-251 MG	Nucleoplasm
	HPA036049	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FBXL18 (HGNC Symbol)
Synonyms	Fbl18, FLJ11467
Description	F-box and leucine-rich repeat protein 18 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	p22.1
Chromosome location (bp)	5431335 - 5513798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155034 (version 83.38)
Entrez gene	80028
UniProt	Q96ME1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96ME1
Antibodypedia	FBXL18 antibodies

PROTEIN BROWSER

FBXL18-003	FBXL18-004	FBXL18-201	FBXL18-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL18-003 ENSP00000371805 ENST00000382368	Q96ME1 [Direct mapping] F-box/LRR-repeat protein 18 A0A024R857 [Target identity:100%; Query identity:100%] F-box and leucine-rich repeat protein 18, isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	718 aa 78.9 kDa	No	0
FBXL18-004 ENSP00000405896 ENST00000458142	H0Y6I6 [Direct mapping] F-box/LRR-repeat protein 18 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	685 aa 74.8 kDa	No	0
FBXL18-201 ENSP00000444797 ENST00000453700	Q96ME1 [Direct mapping] F-box/LRR-repeat protein 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	365 aa 40.2 kDa	No	0
FBXL18-202 ENSP00000481397 ENST00000620087	Q96D16 [Direct mapping] F-box/LRR-repeat protein 18; FBXL18 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	259 aa 26.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.