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AK9

GENERAL INFORMATION

Gene name

 AK9

Gene description

 Adenylate kinase 9

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression along with a few cases of cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 6 antibodies.
HPA030804 , HPA030805 , HPA031779 , HPA031781 , HPA036324 , HPA036711
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA030804
HPA030805
HPA031779
HPA031781
HPA036324
HPA036711

GENE INFORMATION

Gene name

 AK9 (HGNC Symbol)

Synonyms

 AKD1, AKD2, C6orf199, C6orf224, dJ70A9.1, FLJ25791, FLJ42177, MGC26954

Description

 Adenylate kinase 9 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 109492856 - 109691217

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155085 (version 83.38)

Entrez gene

 221264

UniProt

 Q5TCS8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5TCS8

Antibodypedia

 AK9 antibodies

PROTEIN BROWSER
AK9-001
AK9-002
AK9-003
AK9-004
AK9-006
AK9-007
AK9-008
AK9-009
AK9-010
AK9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK9-001
ENSP00000347431
ENST00000355283
Q5TCS8 [Direct mapping]
Adenylate kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006174 [dADP phosphorylation]
GO:0006186 [dGDP phosphorylation]
GO:0006756 [AMP phosphorylation]
GO:0006757 [ATP generation from ADP]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0050145 [nucleoside phosphate kinase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0061508 [CDP phosphorylation]
GO:0061565 [dAMP phosphorylation]
GO:0061566 [CMP phosphorylation]
GO:0061567 [dCMP phosphorylation]
GO:0061568 [GDP phosphorylation]
GO:0061569 [UDP phosphorylation]
GO:0061570 [dCDP phosphorylation]
GO:0061571 [TDP phosphorylation]
Show all
 336 aa
39 kDa 		No 0
AK9-002
ENSP00000418670
ENST00000491875
H7C505 [Direct mapping]
Adenylate kinase 9
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
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GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
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 218 aa
25.3 kDa 		No 0
AK9-003
ENSP00000418771
ENST00000470564
H7C517 [Direct mapping]
Adenylate kinase 9
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 749 aa
87.2 kDa 		No 0
AK9-004
ENSP00000419758
ENST00000490722
H0Y8C5 [Direct mapping]
Adenylate kinase 9
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 312 aa
36.4 kDa 		No 0
AK9-006
ENSP00000357944
ENST00000368948
J3KP89 [Direct mapping]
Adenylate kinase 9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0031965 [nuclear membrane]
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 736 aa
84.9 kDa 		No 0
AK9-007
ENSP00000285397
ENST00000285397
Q5TCS8 [Direct mapping]
Adenylate kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006174 [dADP phosphorylation]
GO:0006186 [dGDP phosphorylation]
GO:0006756 [AMP phosphorylation]
GO:0006757 [ATP generation from ADP]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0050145 [nucleoside phosphate kinase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0061508 [CDP phosphorylation]
GO:0061565 [dAMP phosphorylation]
GO:0061566 [CMP phosphorylation]
GO:0061567 [dCMP phosphorylation]
GO:0061568 [GDP phosphorylation]
GO:0061569 [UDP phosphorylation]
GO:0061570 [dCDP phosphorylation]
GO:0061571 [TDP phosphorylation]
Show all
 421 aa
48.5 kDa 		No 0
AK9-008
ENSP00000407510
ENST00000448084
E9PPM3 [Direct mapping]
Adenylate kinase 9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 227 aa
26.5 kDa 		No 0
AK9-009
ENSP00000431394
ENST00000524674
H0YCD1 [Direct mapping]
Adenylate kinase 9
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 193 aa
22.8 kDa 		No 0
AK9-010
ENSP00000436325
ENST00000532976
E9PPU7 [Direct mapping]
Adenylate kinase 9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
Show all
 259 aa
30 kDa 		No 0
AK9-201
ENSP00000410186
ENST00000424296
Q5TCS8 [Direct mapping]
Adenylate kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006174 [dADP phosphorylation]
GO:0006186 [dGDP phosphorylation]
GO:0006756 [AMP phosphorylation]
GO:0006757 [ATP generation from ADP]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0050145 [nucleoside phosphate kinase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0061508 [CDP phosphorylation]
GO:0061565 [dAMP phosphorylation]
GO:0061566 [CMP phosphorylation]
GO:0061567 [dCMP phosphorylation]
GO:0061568 [GDP phosphorylation]
GO:0061569 [UDP phosphorylation]
GO:0061570 [dCDP phosphorylation]
GO:0061571 [TDP phosphorylation]
Show all
 1911 aa
221.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.