Expression of PTPRN2 in cancer - Summary

GENERAL INFORMATION
Gene name	PTPRN2
Gene description	Protein tyrosine phosphatase, receptor type, N polypeptide 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22, HDLM-2, NB-4, SCLC-21H, SH-SY5Y, U-87 MG)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly cells of CNS and endocrine cells in several tissues, including pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA006900 , HPA026656
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and renal cancer (favourable).
Glioma p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006900	HPA026656

GENE INFORMATION
Gene name	PTPRN2 (HGNC Symbol)
Synonyms	IA-2beta, ICAAR, KIAA0387, phogrin
Description	Protein tyrosine phosphatase, receptor type, N polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	157539056 - 158587788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155093 (version 83.38)
Entrez gene	5799
UniProt	Q92932 (UniProt - Evidence at protein level)
neXtProt	NX_Q92932
Antibodypedia	PTPRN2 antibodies

PROTEIN BROWSER

PTPRN2-002	PTPRN2-003	PTPRN2-004	PTPRN2-005	PTPRN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRN2-002 ENSP00000387114 ENST00000409483	E7EM83 [Direct mapping] Protein-tyrosine-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	977 aa 107 kDa	Yes	1
PTPRN2-003 ENSP00000374064 ENST00000389413	Q92932 [Direct mapping] Receptor-type tyrosine-protein phosphatase N2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0010554 [neurotransmitter secretory pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0030672 [synaptic vesicle membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035773 [insulin secretion involved in cellular response to glucose stimulus] GO:0043235 [receptor complex] Show all	986 aa 108.1 kDa	Yes	1
PTPRN2-004 ENSP00000374067 ENST00000389416	Q92932 [Direct mapping] Receptor-type tyrosine-protein phosphatase N2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0010554 [neurotransmitter secretory pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0030672 [synaptic vesicle membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035773 [insulin secretion involved in cellular response to glucose stimulus] GO:0043235 [receptor complex] Show all	998 aa 109.6 kDa	Yes	1
PTPRN2-005 ENSP00000374069 ENST00000389418	Q92932 [Direct mapping] Receptor-type tyrosine-protein phosphatase N2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0010554 [neurotransmitter secretory pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030141 [secretory granule] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0030672 [synaptic vesicle membrane] GO:0034260 [negative regulation of GTPase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035773 [insulin secretion involved in cellular response to glucose stimulus] GO:0043195 [terminal bouton] GO:0043235 [receptor complex] Show all	1015 aa 111.3 kDa	Yes	1
PTPRN2-201 ENSP00000385464 ENST00000404321	A0A0A0MSD7 [Direct mapping] Receptor-type tyrosine-protein phosphatase N2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		457 aa 49.5 kDa	No	0