Expression of TMEM55A in cancer - Summary - The Human Protein Atlas

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TMEM55A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM55A
Gene description	Transmembrane protein 55A
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA014591
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (unfavourable), head and neck cancer (unfavourable) and stomach cancer (unfavourable).
Liver cancer p<0.001 Cervical cancer p<0.001 Head and neck cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014591

GENE INFORMATION
Gene name	TMEM55A (HGNC Symbol)
Synonyms	DKFZp762O076
Description	Transmembrane protein 55A (HGNC Symbol)
Entrez gene summary	TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q21.3
Chromosome location (bp)	90993796 - 91041064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155099 (version 83.38)
Entrez gene	55529
UniProt	Q8N4L2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4L2
Antibodypedia	TMEM55A antibodies

PROTEIN BROWSER

TMEM55A-001	TMEM55A-004	TMEM55A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM55A-001 ENSP00000285419 ENST00000285419	Q8N4L2 [Direct mapping] Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	257 aa 28.1 kDa	No	2
TMEM55A-004 ENSP00000427974 ENST00000520014	E5RFT4 [Direct mapping] Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	251 aa 27.4 kDa	No	2
TMEM55A-201 ENSP00000486788 ENST00000630164	E5RJC2 [Direct mapping] Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.