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GTF3C6

GENERAL INFORMATION

Gene name

 GTF3C6

Gene description

 General transcription factor IIIC, polypeptide 6, alpha 35kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA056179 , HPA061345
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA056179
HPA061345

GENE INFORMATION

Gene name

 GTF3C6 (HGNC Symbol)

Synonyms

 bA397G5.3, C6orf51, TFIIIC35

Description

 General transcription factor IIIC, polypeptide 6, alpha 35kDa (HGNC Symbol)

Entrez gene summary

 RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 110958560 - 110967890

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155115 (version 83.38)

Entrez gene

 112495

UniProt

 Q969F1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969F1

Antibodypedia

 GTF3C6 antibodies

PROTEIN BROWSER
GTF3C6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GTF3C6-001
ENSP00000357863
ENST00000329970
Q969F1 [Direct mapping]
General transcription factor 3C polypeptide 6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000127 [transcription factor TFIIIC complex]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0042791 [5S class rRNA transcription from RNA polymerase III type 1 promoter]
GO:0042797 [tRNA transcription from RNA polymerase III promoter]
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 213 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.