Expression of AGPAT5 in cancer - Summary - The Human Protein Atlas

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AGPAT5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGPAT5
Gene description	1-acylglycerol-3-phosphate O-acyltransferase 5
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. High expression in endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA010644 , HPA010950
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010644	HPA010950

GENE INFORMATION
Gene name	AGPAT5 (HGNC Symbol)
Synonyms	FLJ11210, LPAAT-e, LPAAT-epsilon
Description	1-acylglycerol-3-phosphate O-acyltransferase 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	6708357 - 6759666
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155189 (version 83.38)
Entrez gene	55326
UniProt	Q9NUQ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUQ2
Antibodypedia	AGPAT5 antibodies

PROTEIN BROWSER

AGPAT5-001	AGPAT5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGPAT5-001 ENSP00000285518 ENST00000285518	Q9NUQ2 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon A0A024R640 [Target identity:100%; Query identity:100%] 1-acylglycerol-3-phosphate O-acyltransferase 5 (Lysophosphatidic acid acyltransferase, epsilon), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0006639 [acylglycerol metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	364 aa 42.1 kDa	No	4
AGPAT5-003 ENSP00000430751 ENST00000518327	H0YC22 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	181 aa 20.3 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.