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PI4K2A

GENERAL INFORMATION

Gene name

 PI4K2A

Gene description

 Phosphatidylinositol 4-kinase type 2 alpha

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic exprssion in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB030649
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PI4K2A (HGNC Symbol)

Synonyms

 DKFZP761G1923, PI4KII, PIK42A

Description

 Phosphatidylinositol 4-kinase type 2 alpha (HGNC Symbol)

Entrez gene summary

 Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 97640686 - 97676434

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155252 (version 83.38)

Entrez gene

 55361

UniProt

 Q9BTU6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BTU6

Antibodypedia

 PI4K2A antibodies

PROTEIN BROWSER
PI4K2A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PI4K2A-001
ENSP00000359665
ENST00000370631
Q9BTU6 [Direct mapping]
Phosphatidylinositol 4-kinase type 2-alpha
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004430 [1-phosphatidylinositol 4-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0031083 [BLOC-1 complex]
GO:0031224 [intrinsic component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0035651 [AP-3 adaptor complex binding]
GO:0035838 [growing cell tip]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044231 [host cell presynaptic membrane]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 479 aa
54 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.