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Malignant tissues displayed moderate granular cytoplasmic staining combined with nuclear positivity in fractions of cases. A few prostate and pancreatic cancers showed strong staining. Malignant gliomas, hepatocellular carcinomas, skin and testicular cancers were weakly stained or negative.
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]