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USP25

GENERAL INFORMATION

Gene name

 USP25

Gene description

 Ubiquitin specific peptidase 25

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA018297 , HPA024142
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018297
HPA024142

GENE INFORMATION

Gene name

 USP25 (HGNC Symbol)

Synonyms

 USP21

Description

 Ubiquitin specific peptidase 25 (HGNC Symbol)

Entrez gene summary

 Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

Chromosome

 21

Cytoband

 q21.1

Chromosome location (bp)

 15730025 - 15880069

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155313 (version 83.38)

Entrez gene

 29761

UniProt

 Q9UHP3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHP3

Antibodypedia

 USP25 antibodies

PROTEIN BROWSER
USP25-001
USP25-002
USP25-003
USP25-005
USP25-006
USP25-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP25-001
ENSP00000285681
ENST00000285681
Q9UHP3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 25
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008233 [peptidase activity]
GO:0016579 [protein deubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032183 [SUMO binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051117 [ATPase binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:1904293 [negative regulation of ERAD pathway]
GO:1904455 [ubiquitin-specific protease activity involved in negative regulation of ERAD pathway]
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 1087 aa
125.7 kDa 		No 0
USP25-002
ENSP00000285679
ENST00000285679
Q9UHP3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 25
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008233 [peptidase activity]
GO:0016579 [protein deubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032183 [SUMO binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051117 [ATPase binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:1904293 [negative regulation of ERAD pathway]
GO:1904455 [ubiquitin-specific protease activity involved in negative regulation of ERAD pathway]
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 1055 aa
122.2 kDa 		No 0
USP25-003
ENSP00000299574
ENST00000351097
Q96B65 [Direct mapping]
USP25 protein; Ubiquitin carboxyl-terminal hydrolase 25
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 450 aa
52.2 kDa 		No 0
USP25-005
ENSP00000404086
ENST00000453553
H7C253 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 25
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 204 aa
23.6 kDa 		No 0
USP25-006
ENSP00000402354
ENST00000449491
H7C1T8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 25
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 229 aa
26.8 kDa 		No 0
USP25-201
ENSP00000383044
ENST00000400183
Q9UHP3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 25
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008233 [peptidase activity]
GO:0016579 [protein deubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032183 [SUMO binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051117 [ATPase binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:1904293 [negative regulation of ERAD pathway]
GO:1904455 [ubiquitin-specific protease activity involved in negative regulation of ERAD pathway]
Show all
 1125 aa
130 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.