Expression of HEATR3 in cancer - Summary - The Human Protein Atlas

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HEATR3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HEATR3
Gene description	HEAT repeat containing 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041990
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041990

GENE INFORMATION
Gene name	HEATR3 (HGNC Symbol)
Synonyms	FLJ20718
Description	HEAT repeat containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	50065941 - 50106387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155393 (version 83.38)
Entrez gene	55027
UniProt	Q7Z4Q2 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4Q2
Antibodypedia	HEATR3 antibodies

PROTEIN BROWSER

HEATR3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HEATR3-001 ENSP00000299192 ENST00000299192	Q7Z4Q2 [Direct mapping] HEAT repeat-containing protein 3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	680 aa 74.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.