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RBM45

GENERAL INFORMATION

Gene name

 RBM45

Gene description

 RNA binding motif protein 45

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear or granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA020448
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020448

GENE INFORMATION

Gene name

 RBM45 (HGNC Symbol)

Synonyms

 DRB1, FLJ44612

Description

 RNA binding motif protein 45 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

Chromosome

 2

Cytoband

 q31.2

Chromosome location (bp)

 178112424 - 178139011

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155636 (version 83.38)

Entrez gene

 129831

UniProt

 Q8IUH3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IUH3

Antibodypedia

 RBM45 antibodies

PROTEIN BROWSER
RBM45-001
RBM45-004
RBM45-006
RBM45-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBM45-001
ENSP00000286070
ENST00000286070
Q8IUH3 [Direct mapping]
RNA-binding protein 45
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
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 474 aa
53.3 kDa 		No 0
RBM45-004
ENSP00000415940
ENST00000455903
H7C476 [Direct mapping]
RNA-binding protein 45
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 135 aa
15 kDa 		No 0
RBM45-006
ENSP00000389134
ENST00000424099
H7BZE0 [Direct mapping]
RNA-binding protein 45
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
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 73 aa
8.1 kDa 		No 0
RBM45-201
ENSP00000482083
ENST00000616198
Q8IUH3 [Direct mapping]
RNA-binding protein 45
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
Show all
 476 aa
53.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.