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PDIA4

GENERAL INFORMATION

Gene name

 PDIA4

Gene description

 Protein disulfide isomerase family A, member 4

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues, high levels in most glandular epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA006139 , HPA006140 , CAB017368
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006139
HPA006140
CAB017368

GENE INFORMATION

Gene name

 PDIA4 (HGNC Symbol)

Synonyms

 ERP70, ERP72

Description

 Protein disulfide isomerase family A, member 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 149003062 - 149028641

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155660 (version 83.38)

Entrez gene

 9601

UniProt

 P13667 (UniProt - Evidence at protein level)

neXtProt

 NX_P13667

Antibodypedia

 PDIA4 antibodies

PROTEIN BROWSER
PDIA4-001
PDIA4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDIA4-001
ENSP00000286091
ENST00000286091
P13667 [Direct mapping]
Protein disulfide-isomerase A4
A0A090N8Y2 [Target identity:100%; Query identity:100%]
Protein disulfide-isomerase A4
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0008152 [metabolic process]
GO:0009306 [protein secretion]
GO:0009986 [cell surface]
GO:0016853 [isomerase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045454 [cell redox homeostasis]
GO:0061077 [chaperone-mediated protein folding]
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 645 aa
72.9 kDa 		Yes 0
PDIA4-002
ENSP00000408628
ENST00000413966
C9JMN9 [Direct mapping]
Protein disulfide-isomerase A4
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   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005623 [cell]
GO:0006457 [protein folding]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045454 [cell redox homeostasis]
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 163 aa
18.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.