Cell atlas - MED7 - The Human Protein Atlas

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MED7

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MED7
Gene description	Mediator complex subunit 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA067181
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067181	CACO-2	Nuclear bodies
	HPA067181	U-2 OS	Nuclear bodies	Intensity
	HPA067181	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	MED7 (HGNC Symbol)
Synonyms	CRSP33, CRSP9
Description	Mediator complex subunit 7 (HGNC Symbol)
Entrez gene summary	The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q33.3
Chromosome location (bp)	157137412 - 157159019
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155868 (version 83.38)
Entrez gene	9443
UniProt	O43513 (UniProt - Evidence at protein level)
neXtProt	NX_O43513
Antibodypedia	MED7 antibodies

PROTEIN BROWSER

MED7-001	MED7-003	MED7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED7-001 ENSP00000286317 ENST00000286317	O43513 [Direct mapping] Mediator of RNA polymerase II transcription subunit 7 Q6IAZ5 [Target identity:100%; Query identity:100%] CRSP9 protein; Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa; Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005739 [mitochondrion] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0019827 [stem cell population maintenance] GO:0031965 [nuclear membrane] GO:0061630 [ubiquitin protein ligase activity] Show all	233 aa 27.2 kDa	No	0
MED7-003 ENSP00000430746 ENST00000524289	E5RIE8 [Direct mapping] Mediator of RNA polymerase II transcription subunit 7 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	195 aa 22.8 kDa	No	0
MED7-201 ENSP00000401046 ENST00000420343	O43513 [Direct mapping] Mediator of RNA polymerase II transcription subunit 7 Q6IAZ5 [Target identity:100%; Query identity:100%] CRSP9 protein; Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa; Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005739 [mitochondrion] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016592 [mediator complex] GO:0031965 [nuclear membrane] Show all	233 aa 27.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.