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Most cases of hepatocellular carcinomas showed strong cytoplasmic staining while a majority of colorectal, lung, endometrial and prostate cancers were moderately stained. Remaining cancer tissues were in general weakly stained or negative.
Gliomas, several cases of colorectal, breast, liver, pancreatic and stomach cancers showed moderate cytoplasmic positivity. Cases of gliomas were strongly stained. Remaining cancers tissues were weakly stained or negative.
GENE INFORMATION
Gene name
RASA2 (HGNC Symbol)
Synonyms
GAP1M
Description
RAS p21 protein activator 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
A0A0A0MSJ9 [Direct mapping] Ras GTPase-activating protein 2
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0035556 [intracellular signal transduction] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0046580 [negative regulation of Ras protein signal transduction]